Clinical and Molecular Anatomy of Gastrointestinal Stromal Tumors (GIST)

Giorgio Maria Paolo Graziano, Giovanni Castelli, Prof Anthony Graziano

Introduction  Gastrointestinal stromal tumors GISTs are rare and fall into the category of non-epithelial tumors of the gastrointestinal tract , involving the stomach at a higher percentage (70 %). The purpose of this study , through a retrospective analysis of the observed cases , is to obtain data on the incidence , survival curve identification of prognostic and predictive parameters .The goal is to collect data concerning the natural history of GIST , 65% of patients were female, 35% male , mean age 64 years. Metastatic disease was assessed by cd171. In this study, n 11 (65 %) cases were L1 ( cd171 ) positive for smooth muscle tumors . Of which 8 with headquarters in the stomach, ileum en 3 . Investigations have been performed immunohistochemistry with CD117 , CD99 , ema .  all enrolled patients tested positive for CD117 .Discussion Thread What are the prognostic factors of GiST is still a matter of debate, but the consensus conference (NIH) in 2001 defined BETHESTHA n 2 parameters which are: the size and mitotic index of 50 HP for the lesions found were reported as accidental the size ranged < 10mm to > 50mm . . . The study carried out shows that the markers are the key to the histological diagnosis of GIST malignancies in GIST have introduced anti-angiogenic therapy with administration of sunitinib at a dose of 50mg/die for 4 weeks every 6 . For the purpose of inhibiting tumor growth with a time of disease-free interval longer. It is evident that in the histological diagnosis of GIST are inserted reporting the results of molecular biology with immunohistochemical markers , in combination with mitotic index , and tumor size in order to define a complete  risks MTS