Preparation and Characterization of Responsive Copolymer Nano-Micelles for Co-Delivery of Anticancer Drugs

Qiu-yue Wang, Yu Fu

polymer micelle, PEI, pH-sensitive, drug delivery.

Chemotherapy is still challenging by low solubility, poor bioavailability and systematic toxicity. Herein, a pH-responsive polymer nano-micelle for drug delivery for combination chemotherapy for cancer. In the microenvironment of tumor cells, the as prepared polymer nano micelle can achieve controlled drug release. Remarkably, the as prepared polymer nano micelle possessed negatively charged under normal physiological conditions while switching into positive charge under acidic tumoral environment to enhance the cell uptake and anti-tumor efficiency. Therefore, the novel block copolymer nano-micelles were synthesized by using PEG, PEI and PLA as the segments. The pH-sensitive structure can achieve the charge reversal. The as prepared drug delivery system exhibited charge switch and controlled drug release, which can be used as a promising candidate for combined treatment of tumor.

https://doi.org/10.31871/IJNTR.8.4.12