The Preparation and Characterization of Meso-Silica Based Nano-Composite

Shuanghui Huang, Si Peng

meso-silica, composites, pH-sensitive, drug delivery.

In recent years, cancer has become the one of the most serious threats to human health on the global scale, which cause increasing mortality rate in hospital. Chemotherapy is still the first line strategy in cancer therapy despite high its serious side effect towards normal tissues. Therefore, we designed a novel meso-silica based nano-composites (MSNCs) to solve the above issues for efficient drug delivery in cancer treatment. The as prepared MSNCs can achieve effective delivery of anti-cancer drug to tumor tissues with prolonged blood circulation time, effective accumulation in tumor sites, and controlled drug release in tumor cells due to their stimuli-responsive structure, excellent biocompatible, and high drug loading. In this work, a pH-sensitive MSNCs was prepared, and the chemo-physical properties of the MSNCs were characterized. Based on the experimental results, the as prepared MSNCs can achieve good dispersity in water, charge switch property, and high drug release rate, which can be used as a promising drug carrier for cancer therapy.

https://doi.org/10.31871/IJNTR.8.4.4