Under The Action Of β-Amyloid Peptide1-40 Hippocampal CA1 Pyramidal Neurons Membrane Ion Conductivity and its Current Dynamic Model

Tong-han Lan , Yue-jing Zhang, Xiao Li,Hao Cai, Fei -fei Yu

In this paper the Acutely isolated hippocampal CA1 pyramidal neurons is researched. under the mode of whole cell recording signals, Aging process of β-amyloid peptide1-40 for Na⁺ Current the effects, Aging process of β-amyloid peptide_1-40 the concentration of as needed 0.01μmol.L^-1.We clamp down on -60 mV, depolarization to - 10 mV, 0 mV, 10 mV, 20 mV, compared before and after the use of  0.01μmol.L^-1 β-amyloid peptide_1-40 hippocampal neurons cell membrane conductivity changing with time. sodium channels in the process of activation is to escalate rapidly open process, the deactivation is to intensify in the process of closing the slow process of sodium channels. two different before and after the main current of 0.01μmol.L^-1 β-amyloid peptide_1-40 (sodium ion current) established the dynamic model of the current.